Some examples of our projects are below:

–CONDOR (COVID-19 National DiagnOstic Research and Evaluation Platform)

Please also see our COVID-19 research page.

–CRUK Convergence Science Centre

–LiSENUS project (Detection of metastatic axillary sentinel lymph nodes using ultrafast, super-resolution, dual-contrast enhanced ultrasound imaging in patients with breast cancer)

More examples provided in the sections below to help you understand more about our work. The examples relate to our different stakeholder types, including industry, clinical partners, NIHR Infrastructures, regulatory (and other) agencies, and academia.

Primary care

• Point-of-care test (POCT) for C-reactive protein. Exploring the potential of a new device in pharmacies.
• Novel hearing test. We analysed stakeholder needs and preferences, and identifying barriers to adoption.

Infectious diseases

• POCT for acute HIV infections. We conducted stakeholder and economic analysis.
• New rapid POCT to identify species-specific bacterial infection. We conducted a clinical study and assessing stakeholder perceptions. We also performed economic analysis.

Cancer (gastrointestinal)

• Breath test for diagnosing gastrointestinal cancers. This research addressed an unmet need for a non-invasive test to triage patients for invasive investigations. We worked closely with colleagues in the department of surgery and cancer at Imperial College to support several studies that aim to validate the breath tests and to maximize safety and usability.

Artificial Intelligence Tools

AI Clinician

Imperial and Oxford AHSNs funded three posts at London IVD to streamline the diagnostics development pathway from AHSNs. These posts helped us to expand our clinical networks and provide access to NHS commissioners.

NIHR-North West London CLAHRC informed grant applications such as SBRI phase II with Highland Biosciences Ltd. The aim is to have a diagnostic device for major trauma patients implemented in the NHS within the next five years. More details about the project is here.

The Medicines & Healthcare products Regulatory Agency (MHRA) funded a post at London IVD to research common faults experienced by end users with diagnostic (and other) devices. This collaboration generated a set of principles to support designers, and identify deficiencies in the current system of adverse event reporting.

The National Institute for Health and Care Excellence (NICE) workeds with us to develop methods to enable the efficient and effective evaluation of diagnostic tests. We developed an action based on a joint workshop. Representatives from other agencies (MHRA, HRA, PHE) also participated in this.

University College London are working with us to aid more precise drug dosing in children with cancer. Please click here for more details on this project “ChromaDose”.

Brunel University worked with us to build an innovative platform to allow flexible economic analysis of diagnostics.

King’s College London worked with us on interruptions and multitasking in the context of diagnostics and other medical devices.

A selection of recent publications involving members of the NIHR London IVD is included below.

2023

Budd, J., Miller, B.S., Weckman, N.E., Cherkaoui, D., Huang, D., Fongwen, N., Han, G.R., Broto, M., Estcourt, C.S. Gibbs, J., Pillay, D., Sonnenberg, P., Meurant, R., Thomas, M., Keegan, N., Stevens, M.M., Nastouli, E., Topol, E., Johnson, A., Shahmanesh, M., Ozcan, A., Collins, J., Suarez, M., Rodriguez, B., Peeling, R. and McKendry, R., 2023. Lateral flow test engineering and lessons learned from COVID-19. Nature Reviews Bioengineering, 1(1), 13-31. doi: 10.1038/s44222-022-00007-3

El-Osta, A., Kerr, G., Alaa, A., El Asmar, M.L., Karki, M., Webber, I., Riboli Sasco, E., Blume, G., Beecken, W.D. and Mummery, D., 2023. Investigating self-reported efficacy of lifestyle medicine approaches to tackle erectile dysfunction: a cross-sectional eSurvey based study. BMC urology, 23(15), 1-12. doi: 10.1186/s12894-023-01180-2

Tase, A., Micocci, M., Buckle, P., Ni, M., & Hanna, G. 2023. Pathway map development for medical device event reporting in operating theatres: a human factors approach to improving the existing system.. BMJ Surg Interv Health Technol, 5(1), e000155. doi:10.1136/bmjsit-2022-000155

2022

Belluomo, I., Boshier, P.R., Myridakis, A., Vadhwana, B., Markar, S.R., Spanel, P. and Hanna, G.B., 2021. Selected ion flow tube mass spectrometry for targeted analysis of volatile organic compounds in human breath. Nature Protocols, 16(7), 3419-3438. doi:10.1038/s41596-021-00542-0

Boshier, P.R., Swaray, A., Vadhwana, B., O’Sullivan, A., Low, D.E., Hanna, G.B. and Peters, C.J., 2022. Systematic review and validation of clinical models predicting survival after oesophagectomy for adenocarcinoma. British Journal of Surgery, 109(5), 418-425. Doi: 10.2139/ssrn.3783088 doi:10.1093/bjs/znac044

Boshier, P.R., Swaray, A., Vadhwana, B., O’Sullivan, A., Low, D.E., Hanna, G.B. and Peters, C.J., 2022. Systematic review and validation of clinical models predicting survival after oesophagectomy for adenocarcinoma. British Journal of Surgery, 109(5), 418-425. doi: 10.1093/bjs/znac044

Broto, M., Kaminski, M.M., Adrianus, C., Kim, N., Greensmith, R., Dissanayake-Perera, S., Schubert, A.J., Tan, X., Kim, H., Dighe, A.S., Collins, J.J. and Stevens, M. 2022. Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs. Nature Nanotechnology, 17(10), 1120-1126. doi: 10.1038/s41565-022-01179-0

Broto, M., Kaminski, M.M., Adrianus, C., Kim, N., Greensmith, R., Dissanayake-Perera, S., Schubert, A.J., Tan, X., Kim, H., Dighe, A.S., Collins, J.J. and Stevens, M. 2022. Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs. Nature Nanotechnology, 17(10), 1120-1126. doi:10.1016/j.jviromet.2022.114475

Burdett, A., Toumazou, C., Sahoo, R., Mujan, A., Hon, T.K., Bedzo-Nutakor, J., Casali, N., Karvela, M., Sohbati, M., Cooke, G.S. and Davies, G.W., 2021. Pooled sputum to optimise the efficiency and utility of rapid, point-of-care molecular SARS-CoV-2 testing. BMC infectious diseases, 21(1), 1-10. doi: 10.1186/s12879-021-06316-z

Davies, B., Araghi, M., Moshe, M., Gao, H., Bennet, K., Jenkins, J., Atchison, C., Darzi, A., Ashby, D., Riley, S. and Barclay, W., Cooke, G.S. 2021, November. Acceptability, usability, and performance of lateral flow immunoassay tests for severe acute respiratory syndrome coronavirus 2 antibodies: REACT-2 study of self-testing in nonhealthcare key workers. In Open forum infectious diseases (Vol. 8, No. 11, p. 496). US: Oxford University Press. doi:10.1093/ofid/ofab496

El-Osta, A., Webber, I., Alaa, A., Bagkeris, E., Mian, S., Sharabiani, M.T.A. and Majeed, A., 2022. What is the suitability of clinical vignettes in benchmarking the performance of online symptom checkers? An audit study. BMJ open, 12(4), 1-11. doi:10.1136/ bmjopen-2021-053566

El-Osta, A., Webber, I., Alaa, A., Bagkeris, E., Mian, S., Sharabiani, M.T.A. and Majeed, A., 2022. What is the suitability of clinical vignettes in benchmarking the performance of online symptom checkers? An audit study. BMJ open, 12(4), 1-11. doi: 10.1136/bmjopen-2021-053566

Elliott, J.A., Markar, S.R., Klevebro, F., Ni, M.Z., Nilsson, M., Zaninotto, G., Hanna, G.B., Reynolds, J.V. and ENSURE Study Group, 2021. INTENSIVE SURVEILLANCE AFTER CURATIVE INTENT SURGERY FOR ESOPHAGEAL CANCER: INITIAL RESULTS OF THE ENSURE STUDY. Diseases of the Esophagus, 34(Supplement_1), 52-546.

Faffe, D., Byrne, R., Body, R., Castineiras, T. M. P., Castineiras, A., Finch, L., . . . Cubas Atienzar, A. 2022. Multicenter Diagnostic Evaluation of a Novel Coronavirus Antigen Lateral Flow Test among Symptomatic Individuals in Brazil and the United Kingdom. MICROBIOLOGY SPECTRUM, 1-8. doi:10.1128/spectrum.02012-22

Harris, A., Butterworth, J., Boshier, P.R., MacKenzie, H., Tokunaga, M., Sunagawa, H., Mavroveli, S., Ni, M., Mikhail, S., Yeh, C.C. and Blencowe, N.S., Hanna, G.B., 2022. Development of a reliable surgical quality assurance system for 2-stage esophagectomy in randomized controlled trials. Annals of Surgery, 275(1), 121-130. doi: 10.1097/SLA.0000000000003850

Joshi, M., Archer, S., Morbi, A., Ashrafian, H., Arora, S., Khan, S., Cooke, G. and Darzi, A., 2022. Perceptions on the use of wearable sensors and continuous monitoring in surgical patients: Interview study among surgical staff. JMIR Formative Research, 6(2), 1-9. doi: 10.2196/27866

Kamal, F., Kumar, S., Edwards, M.R., Veselkov, K., Belluomo, I., Kebadze, T., Romano, A., Trujillo-Torralbo, M.B., Shahridan Faiez, T., Walton, R. and Ritchie, A.I., Hannah, G.B., 2021. Virus-induced volatile organic compounds are detectable in exhaled breath during pulmonary infection. American Journal of Respiratory and Critical Care Medicine, 204(9),1075-1085. doi: 10.1164/rccm.202103-0660OC

Klevebro, F., Boshier, P.R., Savva, K.V., Waller, A., Hage, L., Ni, M., Hanna, G.B. and Low, D.E., 2021. Severe Dumping Symptoms Are Uncommon Following Transthoracic Esophagectomy But Significantly Decrease Health-Related Quality of Life in Long-Term, Disease-Free Survivors. Journal of Gastrointestinal Surgery, 25(8), 1941-1947. doi:10.1007/s11605-020-04670-y

Li, H.K., Kaforou, M., Rodriguez-Manzano, J., Channon-Wells, S., Moniri, A., Habgood-Coote, D., Gupta, R.K., Mills, E.A., Arancon, D., Lin, J. and Chiu, Y.H., Cooke, G.S. 2021. Discovery and validation of a 3-gene transcriptional signature to distinguish COVID-19 and other viral infections from bacterial sepsis in adults; a case-control then observational cohort study. doi:10.1016/S2666-5247(21)00145-2

Lin, G. P., Vadhwana, B., Belluomo, I., Boshier, P.R., Španěl, P., and Hanna, G.B. 2021. Cross Platform Analysis of Volatile Organic Compounds Using Selected Ion Flow Tube and Proton-Transfer-Reaction Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 32(5) 1215-1223. doi: 10.1021/jasms. 1c00027

Mehta, R., Chekmeneva, E., Jackson, H., Sands, C., Mills, E., Arancon, D., Li, H.K., Arkell, P., Rawson, T.M., Hammond, R. and Amran, M., Cooke, G.S. 2022. Antiviral metabolite 3′-deoxy-3′, 4′-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19. Med, 3(3), 204-215. doi:10.1016.j/medj.2022.01.009

Mehta, R., Chekmeneva, E., Jackson, H., Sands, C., Mills, E., Arancon, D., Li, H.K., Arkell, P., Rawson, T.M., Hammond, R. and Amran, M., Cooke, G.S. 2022. Antiviral metabolite 3′-deoxy-3′, 4′-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19. Med, 3(3), 204-215. doi:10.1016/j.medj.2022.01.009

Micocci, M., Buckle, P., Hayward, G., Allen, A.J., Davies, K., Kierkegaard, P., Spilsbury, K., Thompson, C., Astle, A., Heath, R. and Sharpe, C., 2021. Point of Care Testing using rapid automated Antigen Testing for SARS-COV-2 in Care Homes–an exploratory safety, usability and diagnostic agreement evaluation. Journal of Patient Safety and Risk Management, 26(6), 243-250. doi: 10.1177/25160435211054207

Ming, D.K., Jangam, S., Gowers, S.A., Wilson, R., Freeman, D.M., Boutelle, M.G., Cass, A.E., O’Hare, D. and Holmes, A.H., 2022. Real-time continuous measurement of lactate through a minimally invasive microneedle patch: a phase I clinical study. BMJ Innovations, 8(2). doi:10.1136/bmjinnov-2021-000864

Ming, D.K., Jangam, S., Gowers, S.A., Wilson, R., Freeman, D.M., Boutelle, M.G., Cass, A.E., O’Hare, D. and Holmes, A.H., 2022. Real-time continuous measurement of lactate through a minimally invasive microneedle patch: a phase I clinical study. BMJ Innovations, 8(2). doi: 10.1136/bmjinnov-2021-000864

Nwankwo, L., McLaren, K., Donovan, J., Ni, Z., Vidal-Diaz, A., Loebinger, M., Morrisey, A., Igra, A. and Shah, A., 2021. Utilisation of remote capillary blood testing in an outpatient clinic setting to improve shared decision making and patient and clinician experience: a validation and pilot study. BMJ open quality, 10(3), 001-192. doi: 10.1136/bmjoq-2020-001192

Painter, A., Hayhoe, B., Riboli-Sasco, E. and El-Osta, A., 2022. Online Symptom Checkers: Recommendations for a Vignette-Based Clinical Evaluation Standard. Journal of Medical Internet Research, 24(10), 37408. doi: 10.2196/37408

Painter, A., Hayhoe, B., Riboli-Sasco, E. and El-Osta, A., 2022. Online Symptom Checkers: Recommendations for a Vignette-Based Clinical Evaluation Standard. Journal of Medical Internet Research, 24(10), 37408. doi:10.2196/37408

Penders, J., Nagelkerke, A., Cunnane, E.M., Pedersen, S.V., Pence, I.J., Coombes, R.C. and Stevens, M.M., 2021. Single particle automated Raman trapping analysis of breast cancer cell-derived extracellular vesicles as cancer biomarkers. ACS nano, 15(11), 18192-18205. doi: 10.1021/acsnano.1c07075

Rawson, T.M., Wilson, R.C., O’Hare, D., Herrero, P., Kambugu, A., Lamorde, M., Ellington, M., Georgiou, P., Cass, A., Hope, W.W. and Holmes, A.H., 2021. Optimizing antimicrobial use: Challenges, advances and opportunities. Nature Reviews Microbiology, 19(12), 747-758. doi: 10.1038/s41579-021-00578-9

Rosadas, C., Khan, M., Parker, E., Marchesin, F., Katsanovskaja, K., Sureda-Vives, M., Fernandez, N., Randell, P., Harvey, R., Lilley, A. Cooke, G.S., and Harris, B.H., 2022. Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility. Journal of Virological Methods, 302, 114-475. doi: 10.1016/j.jviromet.2022.114475

Rosadas, C., Khan, M., Parker, E., Marchesin, F., Katsanovskaja, K., Sureda-Vives, M., Fernandez, N., Randell, P., Harvey, R., Lilley, A. Cooke, G.S., and Harris, B.H., 2022. Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility. Journal of Virological Methods, 302, 114-475. doi: 10.1016/j.jviromet.2022.114475

Savva, K.V., Das, B., Antonowicz, S., Hanna, G.B. and Peters, C.J., 2022. Progress with Metabolomic Blood Tests for Gastrointestinal Cancer Diagnosis-An Assessment of Biomarker Translation. Cancer Epidemiology, Biomarkers & Prevention. doi:10.1158/1055-9965.EPI-22-0307

Tase, A., Ni, M. Z., Buckle, P. W., and Hanna, G. B., 2022. Current status of medical device malfunction reporting: using end user experience to identify current problems. BMJ OPEN QUALITY, 11(2), 1-8. doi:10.1136/bmjoq-2022-001849

Tase, A., Ni, M. Z., Buckle, P. W., and Hanna, G. B., 2022. Current status of medical device malfunction reporting: using end user experience to identify current problems. BMJ OPEN QUALITY, 11(2), 1-8. doi: 10.1136/bmjoq-2022-001849

Tase, A., Vadhwana, B., Buckle, P., and Hanna, G. B., 2022. Usability challenges in the use of medical devices in the home environment: A systematic review of literature APPLIED ERGONOMICS, 103, 1-8. doi:10.1016/j.apergo.2022.103769

Tase, A., Vadhwana, B., Buckle, P., and Hanna, G. B., 2022. Usability challenges in the use of medical devices in the home environment: A systematic review of literature APPLIED ERGONOMICS, 103, 1-8. doi: 10.1016/j.apergo.2022.103769

Tulloch, J.S., Micocci, M., Buckle, P., Lawrenson, K., Kierkegaard, P., McLister, A., Gordon, A.L., García-Fiñana, M., Peddie, S., Ashton, M. and Buchan, I., 2021. Enhanced lateral flow testing strategies in care homes are associated with poor adherence and were insufficient to prevent COVID-19 outbreaks: results from a mixed methods implementation study. Age and ageing, 50(6), 1868-1875. Doi: 10.1093/ageing/afab162

Woodfield, G., Belluomo, I., Boshier, P.R., Waller, A., Fayyad, M., von Wagner, C., Cross, A.J. and Hanna, G.B., 2021. Feasibility and acceptability of breath research in primary care: a prospective, cross-sectional, observational study. BMJ open, 11(4), 044-691. doi:10.1136/bmjopen-2020-044691

Zamora, B. and Towse, A., 2022. The cost-per-QALY threshold in England: Identifying structural uncertainty in the estimates. Frontiers in Health Services, 2. doi: 10.3389/frhs.2022.936774

Zamora, B. and Towse, A., 2022. The cost-per-QALY threshold in England: Identifying structural uncertainty in the estimates. Frontiers in Health Services, 2. doi: 10.3389/frhs.2022.936774

2021

Aimo, A., Manetti, S. & Emdin, M. 2021. How much is it to mend a broken heart? Results from the US Nationwide Readmission Database. International Journal of Cardiology, 329, 150-151. doi: 10.1016/j.ijcard.2020.12.034

Aksenov, A. A., Laponogov, I., Zhang, Z., Doran, S. L. F., Belluomo, I., Veselkov, D., Bittremieux, W., Nothias, L. F., Nothias-Esposito, M., Maloney, K. N., Misra, B. B., Melnik, A. V., Smirnov, A., Du, X., Jones, K. L., Dorrestein, K., Panitchpakdi, M., Ernst, M., Van Der Hooft, J. J. J., Gonzalez, M., Carazzone, C., Amézquita, A., Callewaert, C., Morton, J. T., Quinn, R. A., Bouslimani, A., Orio, A. A., Petras, D., Smania, A. M., Couvillion, S. P., Burnet, M. C., Nicora, C. D., Zink, E., Metz, T. O., Artaev, V., Humston-Fulmer, E., Gregor, R., Meijler, M. M., Mizrahi, I., Eyal, S., Anderson, B., Dutton, R., Lugan, R., Boulch, P. L., Guitton, Y., Prevost, S., Poirier, A., Dervilly, G., Le Bizec, B., Fait, A., Persi, N. S., Song, C., Gashu, K., Coras, R., Guma, M., Manasson, J., Scher, J. U., Barupal, D. K., Alseekh, S., Fernie, A. R., Mirnezami, R., Vasiliou, V., Schmid, R., Borisov, R. S., Kulikova, L. N., Knight, R., Wang, M., Hanna, G. B., Dorrestein, P. C. & Veselkov, K. 2021. Auto-deconvolution and molecular networking of gas chromatography-mass spectrometry data. Nature Biotechnology, 39(2), 169-173. doi: 10.1038/s41587-020-0700-3

Antonowicz, S., Bodai, Z., Wiggins, T., Markar, S. R., Boshier, P. R., Goh, Y. M., Adam, M. E., Lu, H., Kudo, H., Rosini, F., Goldin, R., Moralli, D., Green, C. M., Peters, C. J., Habib, N., Gabra, H., Fitzgerald, R. C., Takats, Z. & Hanna, G. B. 2021. Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma. Nature Communications, 12(1), 14-54. doi:10.1038/s41467-021-21800-5

Buckle, P., Micocci, M., Tulloch, J., Kierkegaard, P., Parvulescu, P., Thompson, C., . . . Gordon, A. L. 2021. COVID-19 point-of-care testing in care homes: what are the lessons for policy and practice?. AGE AND AGEING, 50(5), 1442-1444. doi:10.1093/ageing/afab101

Hicks, T., Winter, A., Green, K., Kierkegaard, P., Price, D.A., Body, R., Allen, A.J. and Graziadio, S., 2021. Care pathway and prioritization of rapid testing for COVID-19 in UK hospitals: a qualitative evaluation. BMC Health Services Research, 21(1), 1-17. doi: 10.1186/s12913-021-06460-x

Huddy, J. R., Ni, M. Z., Barlow, J. & Hanna, G. B. 2021. Qualitative analysis of stakeholder interviews to identify the barriers and facilitators to the adoption of point-of-care diagnostic tests in the UK. BMJ Open, 11(4), e042944. doi: 10.1136/bmjopen-2020-042944

Kierkegaard, P. & Owen-Smith, J. 2021. Determinants of physician networks: an ethnographic study examining the processes that inform patterns of collaboration and referral decision-making among physicians. BMJ Open, 11(1), e042334. doi: 10.1136/bmjopen-2020-042334

Kierkegaard, P., Mclister, A. & Buckle, P. 2021. Rapid point-of-care testing for COVID-19: quality of supportive information for lateral flow serology assays. BMJ Open, 11(3), e047163. doi: 10.1136/bmjopen-2020-047163

Kierkegaard, P., Micocci, M., McLister, A., Tulloch, J.S.P., Parvulescu, P., Gordon, A. and Buckle, P., 2021. Implementing Lateral Flow Devices in Long-Term Care Facilities: Experiences from the Liverpool COVID-19 Community Testing Pilot in Care Homes-A Qualitative Study. BMC HEALTH SERVICES, 21(1), 1-11. doi:10.1186/s12913-021-07191-9

Kierkegaard P, Hicks T, Allen AJ, Yang Y, Hayward G, Glogowska M, Nicholson BD, Buckle P, CONDOR Steering Committee., 2021. Strategies to implement SARS-CoV-2 point-of-care testing into primary care settings: a qualitative secondary analysis guided by the Behaviour Change Wheel. Implement Sci Communications 2(1), 139. doi: 10.1186/s43058-021-00242-6

Markar, S. R., Vidal-Diez, A., Holt, P. J., Karthikesalingam, A. & Hanna, G. B. 2021. An International Comparison of the Management of Gastrointestinal Surgical Emergencies in Octogenarians-England Versus United States: A National Population-based Cohort Study. Ann Surg, 273(5), 924-932. doi:10.1097/SLA.0000000000003396

Micocci, M., Gordon, A. L., Allen, A. J., Hicks, T., Kierkegaard, P., Mclister, A., Walne, S. & Buckle, P. 2021. COVID-19 testing in English care homes and implications for staff and residents. Age Ageing. 1–5.doi: 10.1093/ageing/afab015

Micocci, M., Gordon, A. L., Seo, M. K., Allen, A. J., Davies, K., Lasserson, D., Thompson, C., Spilsbury, K., Akrill, C., Heath, R., Astle, A., Sharpe, C., Perera, R., Hayward, G. & Buckle, P. 2021. Is Point-of-Care testing feasible and safe in care homes in England? An exploratory usability and accuracy evaluation of a Point-of-Care Polymerase Chain Reaction test for SARS-COV-2. Age Ageing. doi: 10.1093/ageing/afab072

Micocci, M., Borsci, S., Thakerar, V., Walne, S., Manshadi, Y., Edridge, F., Mullarkey, D., Buckle, P. and Hanna, G.B., 2021. Attitudes towards Trusting Artificial Intelligence Insights and Factors to Prevent the Passive Adherence of GPs: A Pilot Study. Journal of Clinical Medicine, 10(14), p.3101. doi:10.3390/jcm10143101

Micocci, M., Buckle, P., Hayward, G., Allen, A. J., Davies, K., Kierkegaard, P., . . . Gordon, A. L. (2021). Point of care testing using rapid automated antigen testing for SARS-COV-2 in care homes – an exploratory safety, usability and diagnostic agreement evaluation. JOURNAL OF PATIENT SAFETY AND RISK MANAGEMENT, 26(6), 243-250. doi:10.1177/25160435211054207

Ni, M., Adam, M.E., Akbar, F., Huddy, J.R., Borsci, S., Buckle, P., Rubulotta, F., Carr, R., Fotheringham, I., Wilson, C. and Tsang, M., 2021. Development and validation of ester impregnated pH strips for locating nasogastric feeding tubes in the stomach—a multicentre prospective diagnostic performance study. Diagnostic and Prognostic Research, 5(1), pp.1-10. doi: 10.1186/s41512-021-00111-9

Tulloch, J. S. P., Micocci, M., Buckle, P., Lawrenson, K., Kierkegaard, P., McLister, A., . . . Parvulescu, P. 2021. Enhanced lateral flow testing strategies in care homes are associated with poor adherence and were insufficient to prevent COVID-19 outbreaks: results from a mixed methods implementation study. AGE AND AGEING, 50(6), 1868-1875. doi:10.1093/ageing/afab162

Tase, A., Buckle, P., Ni, M.Z. and Hanna, G.B., 2021. Medical device error and failure reporting: Learning from the car industry. Journal of Patient Safety and Risk Management, 26(3), 135-141. doi: 10.1177/25160435211008273

2020

Borsci, S., Buckle, P. & Walne, S. 2020. Is the LITE version of the usability metric for user experience (UMUX-LITE) a reliable tool to support rapid assessment of new healthcare technology? Appl Ergon, 84, 103007. https://doi.org/10.1016/j.apergo.2019.103007

Gibani, M.M., Toumazou, C., Sohbati, M., Sahoo, R., Karvela, M., Hon, T.K., De Mateo, S., Burdett, A., Leung, K.F., Barnett, J. and Orbeladze, A., 2020. Assessing a novel, lab-free, point-of-care test for SARS-CoV-2 (CovidNudge): a diagnostic accuracy study. The Lancet Microbe, 1(7), 300-e307. doi: 10.1016/S2666-5247(20)30121-X

Graziadio, S., Urwin, S.G., Cocco, P., Micocci, M., Winter, A., Yang, Y., Price, D.A., Messenger, M., Allen, A.J., Shinkins, B. & Condor Steering Group, 2020. Unmet clinical needs for COVID-19 tests in UK health and social care settings. PloS one, 15(11), p.e0242125. doi: 10.1371/journal.pone.0242125

Grima, M. J., Behrendt, C. A., Vidal-Diez, A., Altreuther, M., Björck, M., Boyle, J. R., Eldrup, N., Karthikesalingam, A., Khashram, M., Loftus, I., Schermerhorn, M., Setacci, C., Szeberin, Z., Debus, S., Venermo, M., Holt, P. & Mani, K. 2020. Editor’s Choice – Assessment of Correlation Between Mean Size of Infrarenal Abdominal Aortic Aneurysm at Time of Intact Repair Against Repair and Rupture Rate in Nine Countries. Eur J Vasc Endovasc Surg, 59, 890-897. doi: 10.1016/j.ejvs.2020.01.024

Hanna, G. B., Mackenzie, H., Miskovic, D., Ni, M., Wyles, S., Aylin, P., Parvaiz, A., Cecil, T., Gudgeon, A., Griffith, J., Robinson, J. M., Selvasekar, C., Rockall, T., Acheson, A., Maxwell-Armstrong, C., Jenkins, J. T., Horgan, A., Cunningham, C., Lindsay, I., Arulampalam, T., Motson, R. W., Francis, N. K., Kennedy, R. H., Coleman, M. G. & Program, L. 2020. Laparoscopic Colorectal Surgery Outcomes Improved After National Training Program (LAPCO) for Specialists in England. Annals of Surgery, 275(6), 1149-1155. doi:10.1097/SLA.0000000000004584

Knight, W. R. C., Mcewen, R., Byrne, B. E., Habib, W., Bott, R., Zylstra, J., Mahadeva, U., Gossage, J. A. & Consortium, O. C. C. A. M. S. O. 2020. Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus. European Journal of Surgical Oncology, 46(12), 2257-2261. doi: 10.1016/j.ejso.2020.07.003

Manetti, S., Turchetti, G. & Fusco, F. 2020a. Determining the cost-effectiveness requirements of an exoskeleton preventing second hip fractures using value of information. BMC Health Services Research, 20, 1-11. doi: 10.1186/s12913-020-05768-4

Manetti, S., Vainieri, M., Guidotti, E., Zuccarino, S., Ferré, F., Morelli, M. S. & Emdin, M. 2020b. Research protocol for the validation of a new portable technology for real-time continuous monitoring of Early Warning Score (EWS) in hospital practice and for an early-stage multistakeholder assessment. BMJ Open, 10, e040738. doi: 10.1136/bmjopen-2020-040738

Markar, S. R., Zaninotto, G., Castoro, C., Johar, A., Lagergren, P., Elliott, J. A., Gisbertz, S. S., Mariette, C., Alfieri, R., Huddy, J., Sounderajah, V., Pinto, E., Scarpa, M., Klevebro, F., Sunde, B., Murphy, C. F., Greene, C., Ravi, N., Piessen, G., Brenkman, H., Ruurda, J. P., Van Hillegersberg, R., Lagarde, S., Wijnhoven, B., Pera, M., Roig, J., Castro, S., Matthijsen, R., Findlay, J., Antonowicz, S., Maynard, N., Mccormack, O., Ariyarathenam, A., Sanders, G., Cheong, E., Jaunoo, S., Allum, W., Van Lanschot, J., Nilsson, M., Reynolds, J. V., Van Berge Henegouwen, M. I. & Hanna, G. B. 2020. Lasting Symptoms After Esophageal Resection (LASER): European Multicenter Cross-sectional Study. Annals of Surgery, 275(2), p392-400. doi: 10.1097/SLA.0000000000003917

Ni, M., Borsci, S., Walne, S., Mclister, A. P., Buckle, P., Barlow, J. G. & Hanna, G. B. 2020. The Lean and Agile Multi-dimensional Process (LAMP) – a new framework for rapid and iterative evidence generation to support health-care technology design and development. Expert Rev Med Devices, 17, 277-288.  doi: 10.1080/17434440.2020.1743174

Abbassi-Ghadi, N., Antonowicz, S. S., Mckenzie, J. S., Kumar, S., Huang, J., Jones, E. A., Strittmatter, N., Petts, G., Kudo, H., Court, S., Hoare, J. M., Veselkov, K., Goldin, R., Takáts, Z. & Hanna, G. B. 2020. Lipogenesis Alters the Phospholipidome of Esophageal Adenocarcinoma. Cancer Res, 80, 2764-2774. doi: 10.1158/0008-5472.CAN-19-4035

Vadhwana, B., Belluomo, I., Boshier, P. R., Pavlou, C., Španěl, P. & Hanna, G. B. 2020. Impact of oral cleansing strategies on exhaled volatile organic compound levels. Rapid Commun Mass Spectrom, 34(9), e8706. doi: 10.1002/rcm.8706

Vijayasingam, A., Frost, E., Wilkins, J., Gillen, L., Premachandra, P., Mclaren, K., Gilmartin, D., Picinali, L., Vidal-Diez, A., Borsci, S., Ni, M. Z., Tang, W. Y., Morris-Rosendahl, D., Harcourt, J., Elston, C., Simmonds, N. J. & Shah, A. 2020a. Tablet and web-based audiometry to screen for hearing loss in adults with cystic fibrosis. Thorax, 75(8), 632-639. doi: 10.1136/thoraxjnl-2019-214177

Wen, Q., Boshier, P., Myridakis, A., Belluomo, I. & Hanna, G. B. 2020. Urinary Volatile Organic Compound Analysis for the Diagnosis of Cancer: A Systematic Literature Review and Quality Assessment. Metabolites, 11(1). doi: 10.3390/metabo11010017

Wu, A.W., Buckle, P., Haut, E.R., Bellandi, T., Koizumi, S., Mair, A., Øvretveit, J., Power, C., Sax, H., Thomas, E.J. and Newman-Toker, D., 2020. Supporting the Emotional Well-being of Health Care Workers During the COVID-19 Pandemic Journal of Patient Safety and Risk Management, 25(3), 93-96. doi: 10.1177/2516043520931971​

2019

Hanna, G. B., Boshier, P. R., Markar, S. R. & Romano, A. 2019. Accuracy and Methodologic Challenges of Volatile Organic Compound-Based Exhaled Breath Tests for Cancer Diagnosis: A Systematic Review and Meta-analysis. JAMA Oncology, 5(1), e182815. doi: 10.1001/jamaoncol.2018.2815

Huddy, J. R., Ni, M., Misra, S., Mavroveli, S., Barlow, J. & Hanna, G. B. 2019. Development of the Point-of-Care Key Evidence Tool (POCKET): a checklist for multi-dimensional evidence generation in point-of-care tests. Clin Chem Lab Med, 57(6), 845-855. doi: 10.1515/cclm-2018-1089

Markar, S. R., Vidal-Diez, A., Patel, K., Maynard, W., Tukanova, K., Murray, A., Holt, P. J., Karthikesalingam, A. & Hanna, G. B. 2019a. Comparison of Surgical Intervention and Mortality for Seven Surgical Emergencies in England and the United States. Annals of Surg, 270(5), 806-812. doi: 10.1097/SLA.0000000000003518

Markar, S. R., Vidal-Diez, A., Sounderajah, V., Mackenzie, H., Hanna, G. B., Thompson, M., Holt, P., Lagergren, J. & Karthikesalingam, A. 2019b. A population-based cohort study examining the risk of abdominal cancer after endovascular abdominal aortic aneurysm repair. Journal of Vascular Surgery, 69(6), 1776-1785. doi: 10.1016/j.jvs.2018.09.058

Micocci, M., Tase, A., Ni, M., Buckle, P., Rubulotta F., 2019. Shaping the Human Side of Medical Devices in Critical Care: The Implication of Human Factors Studies in Health Care Settings. ICU Management & Practice 4, 248-250. Available at: https://healthmanagement.org/c/icu/issuearticle/shaping-the-human-side-of-medical-devices-in-critical-care-the-implication-of-human-factor-studies

Roberts, H. W., Wagh, V. B., Sung, J., Ni, M. Z. & O’brart, D. P. S. 2019. Risk-Adjusted CUSUM Analysis of the Learning Curve of Femtosecond Laser Assisted Cataract Surgery. Curr Eye Res, 44(8), 887-895. doi: 10.1080/02713683.2019.1601742

Subbe, C. P., Bannard-Smith, J., Bunch, J., Champunot, R., Devita, M. A., Durham, L., Edelson, D. P., Gonzalez, I., Hancock, C., Haniffa, R., Hartin, J., Haskell, H., Hogan, H., Jones, D. A., Kalkman, C. J., Lighthall, G. K., Malycha, J., Ni, M. Z., Phillips, A. V., Rubulotta, F., So, R. K., Welch, J. & International Society For Rapid Response, S. 2019. Quality metrics for the evaluation of Rapid Response Systems: Proceedings from the third international consensus conference on Rapid Response Systems. Resuscitation, 141, 1-12. doi: 10.1016/j.resuscitation.2019.05.012

Wu, A.W., Bellandi, T., Buckle, P., Francis, R., Haut, E.R., Kachalia, A., Mair, A., Øvretveit, J., Power, C., Pronovost, P.J. and Sax, H., 2019. Patient safety pearls. Journal of Patient Safety and Risk Management, 24(6), 221–223. doi: 10.1177/2516043519895121

2018

Borsci, S., Buckle, P., Uchegbu, I., Ni, M., Walne, S., & Hanna, G. B. 2018. Integrating human factors and health economics to inform the design of medical device: a conceptual framework. In H. Eskola, O. Vaisanen, J. Viik, & J. Hyttinen (Eds.), EMBEC & NBC 2017Vol. 65 (pp. 49-52). Tampere, FINLAND: SPRINGER-VERLAG SINGAPORE PTE LTD. doi:10.1007/978-981-10-5122-7_13

Borsci, S., Buckle, P., Walne, S., & Salanitri, D. 2018. Trust and Human Factors in the Design of Healthcare Technology. In S. Bagnara, R. Tartaglia, S. Albolino, T. Alexander, & Y. Fujita (Eds.), Proceedings of the 20th Congress of the International Ergonomics Association (IEA 2018): Volume VII: Ergonomics in Design, Design for All, Activity Theories for Work Analysis and Design, Affective Design (pp. 207-215). doi: 10.1007/978-3-319-96071-5_21  

Borsci, S., Uchegbu, I., Buckle, P., Ni, Z., Walne, S. & Hanna, G. B. 2018. Designing medical technology for resilience: integrating health economics and human factors approaches. Expert Rev Med Devices, 15, 15-26. doi: 10.1080/17434440.2018.1418661

Buckle, P., S. Walne, S. Borsci, and J. Anderson. 2018. Human factors and design in future health care. http://www.nationalacademies.org/hmd/~/media/Files/Activity%20Files/Global/GlobalQualityofCare/Meeting%203/Buckle%20presentationHuman%20Factors.pdf (accessed March 15, 2018).

Buckle, P., Borsci, S., Walne, S. and Hanna, G. 2018. Designing medical devices for unmet healthcare needs: an ergonomist’s perspective. . In S. Bagnara, R. Tartaglia, S. Albolino, T. Alexander, & Y. Fujita (Eds.), Proceedings of the 20th Congress of the International Ergonomics Association (IEA 2018): Volume VII: Ergonomics in Design, Design for All, Activity Theories for Work Analysis and Design, Affective Design

Boshier, P. R., Fehervari, M., Markar, S. R., Purkayastha, S., Spanel, P., Smith, D. & Hanna, G. B. 2018. Variation in Exhaled Acetone and Other Ketones in Patients Undergoing Bariatric Surgery: a Prospective Cross-sectional Study. Obesity Surgery, 28, 2439-2446. doi: 10.1007/s11695-018-3180-5

Markar, S. R., Brodie, B., Chin, S. T., Romano, A., Spalding, D. & Hanna, G. B. 2018. Profile of exhaled-breath volatile organic compounds to diagnose pancreatic cancer. Journal of British Surgery, 105(11), 1493-1500. doi: 10.1002/bjs.10909

Markar, S. R., Mackenzie, H., Ni, M., Huddy, J. R., Askari, A., Faiz, O., Griffin, S. M., Lovat, L. & Hanna, G. B.2018b. The influence of procedural volume and proficiency gain on mortality from upper GI endoscopic mucosal resection. Gut, 67(1), 79-85. doi: 10.1136/gutjnl-2015-311237

Markar, S. R., Wiggins, T., Antonowicz, S., Chin, S. T., Romano, A., Nikolic, K., Evans, B., Cunningham, D.,Mughal, M., Lagergren, J. & Hanna, G. B. 2018c. Assessment of a Noninvasive Exhaled Breath Test for the Diagnosis of Oesophagogastric Cancer. JAMA Oncol, 4(7), 970-976. doi: 10.1001/jamaoncol.2018.0991

Roberts, H. W., Wagh, V. K., Mullens, I. J. M., Borsci, S., Ni, M. Z. & O’brart, D. P. S. 2018. Evaluation of a hub-and-spoke model for the delivery of femtosecond laser-assisted cataract surgery within the context of a large randomised controlled trial. British Journal of Ophthalmology, 102(11), 1556-1563. doi:10.1136/bjophthalmol-2017-311319

Uchegbu, I., Sato, M., Allam, A., Buckle, P. & Hanna, G., 2018. The challenges of patient and public involvement in medical technology and in-vitro diagnostic research. Research for All, 2(2), pp.335-346. doi: 10.18546/R4A.02.2.11.