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Our Research


Our projects

Some examples of our projects are below:

 

CONDOR (COVID-19 National DiagnOstic Research and Evaluation Platform)

Please also see our COVID-19 research page.

CRUK Convergence Science Centre

LiSENUS project (Detection of metastatic axillary sentinel lymph nodes using ultrafast, super-resolution, dual-contrast enhanced ultrasound imaging in patients with breast cancer)

 

More examples provided in the sections below to help you understand more about our work. The examples relate our different stakeholder types, including industry, clinical partners, NIHR Infrastructures, regulatory (and other) agencies, and academia.

 


Projects with Industry

Primary care

  • Point-of-care test (POCT) for C-reactive protein. Exploring the potential of a new device in pharmacies.
  • Novel hearing test. We analysed stakeholder needs and preferences, and identifying barriers to adoption.

Infectious diseases

  • POCT for acute HIV infections. We conducted stakeholder and economic analysis.
  • New rapid POCT to identify species-specific bacterial infection. We conducted a clinical study and assessing stakeholder perceptions. We also performed economic analysis.

Projects with Clinical Partners

Cancer (gastrointestinal)

  • Breath test for diagnosing gastrointestinal cancers. This research addressed an unmet need for a non-invasive test to triage patients for invasive investigations. We worked closely with colleagues in the department of surgery and cancer at Imperial College to support several studies that aim to validate the breath tests and to maximize safety and usability.

Projects with other NIHR infrastructures

Imperial and Oxford AHSNs funded three posts at London IVD to streamline the diagnostics development pathway from AHSNs. These posts helped us to expand our clinical networks and provide access to NHS commissioners.

NIHR-North West London CLAHRC informed grant applications such as SBRI phase II with Highland Biosciences Ltd. The aim is to have a diagnostic device for major trauma patients implemented in the NHS within the next five years. More details about the project is here.


Projects with agencies

The Medicines & Healthcare products Regulatory Agency (MHRA) funded a post at London IVD to research common faults experienced by end users with diagnostic (and other) devices. This collaboration generated a set of principles to support designers, and identify deficiencies in the current system of adverse event reporting.

The National Institute for Health and Care Excellence (NICE) workeds with us to develop methods to enable the efficient and effective evaluation of diagnostic tests. We developed an action based on a joint workshop. Representatives from other agencies (MHRA, HRA, PHE) also participated in this.


Projects with other academic institutions

University College London are working with us to aid more precise drug dosing in children with cancer. Please click here for more details on this project “ChromaDose”.

Brunel University worked with us to build an innovative platform to allow flexible economic analysis of diagnostics.

King’s College London worked with us on interruptions and multitasking in the context of diagnostics and other medical devices.

 


Projects you can get involved with

Study Recruitment Request

 

(This is now closed.)

 

Study Title: Development of a patient centred usability evaluation tool for home medical devices

Principal Investigator: Dr Arkeliana Tase

Project Supervisors: Prof Peter Buckle, Dr Melody Zhifang, and Prof George Hanna

 

We are looking for patients, relatives and members of the public to take part in our study to help refine the usability tool we are developing for home use medical devices and technology.

The aim of this tool will be to empower patients to have their voices heard on their experiences and help manufacturers of medical devices improve the design of their devices based on patient requirements.

If you are interested in taking part, please contact Dr Arkeliana Tase at a.tase@imperial.ac.uk to organise a short discussion (20-30 minutes) on the tool being developed.

All responses will be confidential and you will not be identified in the presentation of results for this study.  

 


Publications

A selection of recent publications involving members of the NIHR London IVD is included below.

 

2021

 

Aimo, A., Manetti, S. & Emdin, M. 2021. How much is it to mend a broken heart? Results from the US Nationwide Readmission Database. Int J Cardiol, 329, 150-151.

 

Aksenov, A. A., Laponogov, I., Zhang, Z., Doran, S. L. F., Belluomo, I., Veselkov, D., Bittremieux, W., Nothias, L. F., Nothias-Esposito, M., Maloney, K. N., Misra, B. B., Melnik, A. V., Smirnov, A., Du, X., Jones, K. L., Dorrestein, K., Panitchpakdi, M., Ernst, M., Van Der Hooft, J. J. J., Gonzalez, M., Carazzone, C., Amézquita, A., Callewaert, C., Morton, J. T., Quinn, R. A., Bouslimani, A., Orio, A. A., Petras, D., Smania, A. M., Couvillion, S. P., Burnet, M. C., Nicora, C. D., Zink, E., Metz, T. O., Artaev, V., Humston-Fulmer, E., Gregor, R., Meijler, M. M., Mizrahi, I., Eyal, S., Anderson, B., Dutton, R., Lugan, R., Boulch, P. L., Guitton, Y., Prevost, S., Poirier, A., Dervilly, G., Le Bizec, B., Fait, A., Persi, N. S., Song, C., Gashu, K., Coras, R., Guma, M., Manasson, J., Scher, J. U., Barupal, D. K., Alseekh, S., Fernie, A. R., Mirnezami, R., Vasiliou, V., Schmid, R., Borisov, R. S., Kulikova, L. N., Knight, R., Wang, M., Hanna, G. B., Dorrestein, P. C. & Veselkov, K. 2021. Auto-deconvolution and molecular networking of gas chromatography-mass spectrometry data. Nat Biotechnol, 39, 169-173.

 

Antonowicz, S., Bodai, Z., Wiggins, T., Markar, S. R., Boshier, P. R., Goh, Y. M., Adam, M. E., Lu, H., Kudo, H., Rosini, F., Goldin, R., Moralli, D., Green, C. M., Peters, C. J., Habib, N., Gabra, H., Fitzgerald, R. C., Takats, Z. & Hanna, G. B. 2021. Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma. Nat Commun, 12, 1454.

 

Hicks, T., Winter, A., Green, K., Kierkegaard, P., Price, D.A., Body, R., Allen, A.J. and Graziadio, S., 2021. Care pathway and prioritization of rapid testing for COVID-19 in UK hospitals: a qualitative evaluation. BMC Health Services Research21(1), pp.1-17.

 

Huddy, J. R., Ni, M. Z., Barlow, J. & Hanna, G. B. 2021. Qualitative analysis of stakeholder interviews to identify the barriers and facilitators to the adoption of point-of-care diagnostic tests in the UK. BMJ Open, 11, e042944.

 

Kierkegaard, P. & Owen-Smith, J. 2021. Determinants of physician networks: an ethnographic study examining the processes that inform patterns of collaboration and referral decision-making among physicians. BMJ Open, 11, e042334.

 

Kierkegaard, P., Mclister, A. & Buckle, P. 2021. Rapid point-of-care testing for COVID-19: quality of supportive information for lateral flow serology assays. BMJ Open, 11, e047163.

 

Markar, S. R., Vidal-Diez, A., Holt, P. J., Karthikesalingam, A. & Hanna, G. B. 2021. An International Comparison of the Management of Gastrointestinal Surgical Emergencies in Octogenarians-England Versus United States: A National Population-based Cohort Study. Ann Surg, 273, 924-932.

 

Micocci, M., Gordon, A. L., Allen, A. J., Hicks, T., Kierkegaard, P., Mclister, A., Walne, S. & Buckle, P. 2021. COVID-19 testing in English care homes and implications for staff and residents. Age Ageing. 2021;:1–5.

 

Micocci, M., Gordon, A. L., Seo, M. K., Allen, A. J., Davies, K., Lasserson, D., Thompson, C., Spilsbury, K., Akrill, C., Heath, R., Astle, A., Sharpe, C., Perera, R., Hayward, G. & Buckle, P. 2021c. Is Point-of-Care testing feasible and safe in care homes in England? An exploratory usability and accuracy evaluation of a Point-of-Care Polymerase Chain Reaction test for SARS-COV-2. Age Ageing.

 

Tase, A., Buckle, P., Ni, M.Z. and Hanna, G.B., 2021. Medical device error and failure reporting: Learning from the car industry. Journal of Patient Safety and Risk Management, p.25160435211008273.

 

2020

 

 

Borsci, S., Buckle, P. & Walne, S. 2020. Is the LITE version of the usability metric for user experience (UMUX-LITE) a reliable tool to support rapid assessment of new healthcare technology? Appl Ergon, 84, 103007. https://doi.org/10.1016/j.apergo.2019.103007

 

Graziadio, S., Urwin, S.G., Cocco, P., Micocci, M., Winter, A., Yang, Y., Price, D.A., Messenger, M., Allen, A.J., Shinkins, B. & Condor Steering Group, 2020. Unmet clinical needs for COVID-19 tests in UK health and social care settings. PloS one, 15(11), p.e0242125.

 

Grima, M. J., Behrendt, C. A., Vidal-Diez, A., Altreuther, M., Björck, M., Boyle, J. R., Eldrup, N., Karthikesalingam, A., Khashram, M., Loftus, I., Schermerhorn, M., Setacci, C., Szeberin, Z., Debus, S., Venermo, M., Holt, P. & Mani, K. 2020. Editor’s Choice – Assessment of Correlation Between Mean Size of Infrarenal Abdominal Aortic Aneurysm at Time of Intact Repair Against Repair and Rupture Rate in Nine Countries. Eur J Vasc Endovasc Surg, 59, 890-897.

 

Hanna, G. B., Mackenzie, H., Miskovic, D., Ni, M., Wyles, S., Aylin, P., Parvaiz, A., Cecil, T., Gudgeon, A., Griffith, J., Robinson, J. M., Selvasekar, C., Rockall, T., Acheson, A., Maxwell-Armstrong, C., Jenkins, J. T., Horgan, A., Cunningham, C., Lindsay, I., Arulampalam, T., Motson, R. W., Francis, N. K., Kennedy, R. H., Coleman, M. G. & Program, L. 2020. Laparoscopic Colorectal Surgery Outcomes Improved After National Training Program (LAPCO) for Specialists in England. Ann Surg.

 

Knight, W. R. C., Mcewen, R., Byrne, B. E., Habib, W., Bott, R., Zylstra, J., Mahadeva, U., Gossage, J. A. & Consortium, O. C. C. A. M. S. O. 2020. Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus. Eur J Surg Oncol, 46, 2257-2261.

 

Manetti, S., Turchetti, G. & Fusco, F. 2020a. Determining the cost-effectiveness requirements of an exoskeleton preventing second hip fractures using value of information. BMC Health Serv Res, 20, 955.

 

Manetti, S., Vainieri, M., Guidotti, E., Zuccarino, S., Ferré, F., Morelli, M. S. & Emdin, M. 2020b. Research protocol for the validation of a new portable technology for real-time continuous monitoring of Early Warning Score (EWS) in hospital practice and for an early-stage multistakeholder assessment. BMJ Open, 10, e040738.

 

Markar, S. R., Zaninotto, G., Castoro, C., Johar, A., Lagergren, P., Elliott, J. A., Gisbertz, S. S., Mariette, C., Alfieri, R., Huddy, J., Sounderajah, V., Pinto, E., Scarpa, M., Klevebro, F., Sunde, B., Murphy, C. F., Greene, C., Ravi, N., Piessen, G., Brenkman, H., Ruurda, J. P., Van Hillegersberg, R., Lagarde, S., Wijnhoven, B., Pera, M., Roig, J., Castro, S., Matthijsen, R., Findlay, J., Antonowicz, S., Maynard, N., Mccormack, O., Ariyarathenam, A., Sanders, G., Cheong, E., Jaunoo, S., Allum, W., Van Lanschot, J., Nilsson, M., Reynolds, J. V., Van Berge Henegouwen, M. I. & Hanna, G. B. 2020. Lasting Symptoms After Esophageal Resection (LASER): European Multicenter Cross-sectional Study. Ann Surg.

 

Ni, M., Borsci, S., Walne, S., Mclister, A. P., Buckle, P., Barlow, J. G. & Hanna, G. B. 2020. The Lean and Agile Multi-dimensional Process (LAMP) – a new framework for rapid and iterative evidence generation to support health-care technology design and development. Expert Rev Med Devices, 17, 277-288.  doi: 10.1080/17434440.2020.1743174

 

Abbassi-Ghadi, N., Antonowicz, S. S., Mckenzie, J. S., Kumar, S., Huang, J., Jones, E. A., Strittmatter, N., Petts, G., Kudo, H., Court, S., Hoare, J. M., Veselkov, K., Goldin, R., Takáts, Z. & Hanna, G. B. 2020. Lipogenesis Alters the Phospholipidome of Esophageal Adenocarcinoma. Cancer Res, 80, 2764-2774.

 

Vadhwana, B., Belluomo, I., Boshier, P. R., Pavlou, C., Španěl, P. & Hanna, G. B. 2020. Impact of oral cleansing strategies on exhaled volatile organic compound levels. Rapid Commun Mass Spectrom, 34, e8706.

 

Vijayasingam, A., Frost, E., Wilkins, J., Gillen, L., Premachandra, P., Mclaren, K., Gilmartin, D., Picinali, L., Vidal-Diez, A., Borsci, S., Ni, M. Z., Tang, W. Y., Morris-Rosendahl, D., Harcourt, J., Elston, C., Simmonds, N. J. & Shah, A. 2020a. Tablet and web-based audiometry to screen for hearing loss in adults with cystic fibrosis. Thorax, 75, 632-639.

 

Wen, Q., Boshier, P., Myridakis, A., Belluomo, I. & Hanna, G. B. 2020. Urinary Volatile Organic Compound Analysis for the Diagnosis of Cancer: A Systematic Literature Review and Quality Assessment. Metabolites, 11.

 

Wu, A.W., Buckle, P., Haut, E.R., Bellandi, T., Koizumi, S., Mair, A., Øvretveit, J., Power, C., Sax, H., Thomas, E.J. and Newman-Toker, D., 2020. Supporting the Emotional Well-being of Health Care Workers During the COVID-19 Pandemic Journal of Patient Safety and Risk Management  https://doi.org/10.1177/2516043520931971​

 

2019

 

 

Hanna, G. B., Boshier, P. R., Markar, S. R. & Romano, A. 2019. Accuracy and Methodologic Challenges of Volatile Organic Compound-Based Exhaled Breath Tests for Cancer Diagnosis: A Systematic Review and Meta-analysis. JAMA Oncol, 5, e182815.

 

Huddy, J. R., Ni, M., Misra, S., Mavroveli, S., Barlow, J. & Hanna, G. B. 2019. Development of the Point-of-Care Key Evidence Tool (POCKET): a checklist for multi-dimensional evidence generation in point-of-care tests. Clin Chem Lab Med, 57, 845-855.

 

Markar, S. R., Vidal-Diez, A., Patel, K., Maynard, W., Tukanova, K., Murray, A., Holt, P. J., Karthikesalingam, A. & Hanna, G. B. 2019a. Comparison of Surgical Intervention and Mortality for Seven Surgical Emergencies in England and the United States. Ann Surg, 270, 806-812.

 

Markar, S. R., Vidal-Diez, A., Sounderajah, V., Mackenzie, H., Hanna, G. B., Thompson, M., Holt, P., Lagergren, J. & Karthikesalingam, A. 2019b. A population-based cohort study examining the risk of abdominal cancer after endovascular abdominal aortic aneurysm repair. J Vasc Surg, 69, 1776-1785.e2.

 

Micocci, M., Tase, A., Ni, M., Buckle, P., Rubulotta F., 2019. Shaping the Human Side of Medical Devices in Critical Care: The Implication of Human Factors Studies in Health Care Settings. ICU Management & Practice 4, 248-250

 

Roberts, H. W., Wagh, V. B., Sung, J., Ni, M. Z. & O’brart, D. P. S. 2019. Risk-Adjusted CUSUM Analysis of the Learning Curve of Femtosecond Laser Assisted Cataract Surgery. Curr Eye Res, 44, 887-895.

 

Subbe, C. P., Bannard-Smith, J., Bunch, J., Champunot, R., Devita, M. A., Durham, L., Edelson, D. P., Gonzalez, I., Hancock, C., Haniffa, R., Hartin, J., Haskell, H., Hogan, H., Jones, D. A., Kalkman, C. J., Lighthall, G. K., Malycha, J., Ni, M. Z., Phillips, A. V., Rubulotta, F., So, R. K., Welch, J. & International Society For Rapid Response, S. 2019. Quality metrics for the evaluation of Rapid Response Systems: Proceedings from the third international consensus conference on Rapid Response Systems. Resuscitation, 141, 1-12.

 

Wu, A.W., Bellandi, T., Buckle, P., Francis, R., Haut, E.R., Kachalia, A., Mair, A., Øvretveit, J., Power, C., Pronovost, P.J. and Sax, H., 2019. Patient safety pearls. Journal of Patient Safety and Risk Management24(6), 221–223. https://doi.org/10.1177/2516043519895121

 

2018

 

 

Borsci, S., Buckle, P., Walne, S., & Salanitri, D. 2018. Trust and Human Factors in the Design of Healthcare Technology. In S. Bagnara, R. Tartaglia, S. Albolino, T. Alexander, & Y. Fujita (Eds.), Proceedings of the 20th Congress of the International Ergonomics Association (IEA 2018): Volume VII: Ergonomics in Design, Design for All, Activity Theories for Work Analysis and Design, Affective Design (pp. 207-215). https://doi.org/10.1007/978-3-319-96071-5_21

 

Borsci, S., Uchegbu, I., Buckle, P., Ni, Z., Walne, S. & Hanna, G. B. 2018. Designing medical technology for resilience: integrating health economics and human factors approaches. Expert Rev Med Devices, 15, 15-26. www.tandfonline.com/doi/abs/10.1080/17434440.2018.1418661

 

Buckle, P., S. Walne, S. Borsci, and J. Anderson. 2018. Human factors and design in future health care. http://www.nationalacademies.org/hmd/~/media/Files/Activity%20Files/Global/GlobalQualityofCare/Meeting%203/Buckle%20presentationHuman%20Factors.pdf (accessed March 15, 2018).

 

Buckle, P., Borsci, S., Walne, S. and Hanna, G. 2018. Designing medical devices for unmet healthcare needs: an ergonomist’s perspective. . In S. Bagnara, R. Tartaglia, S. Albolino, T. Alexander, & Y. Fujita (Eds.), Proceedings of the 20th Congress of the International Ergonomics Association (IEA 2018): Volume VII: Ergonomics in Design, Design for All, Activity Theories for Work Analysis and Design, Affective Design

 

Boshier, P. R., Fehervari, M., Markar, S. R., Purkayastha, S., Spanel, P., Smith, D. & Hanna, G. B. 2018. Variation in Exhaled Acetone and Other Ketones in Patients Undergoing Bariatric Surgery: a Prospective Cross-sectional Study. Obes Surg, 28, 2439-2446.

 

Markar, S. R., Brodie, B., Chin, S. T., Romano, A., Spalding, D. & Hanna, G. B. 2018a. Profile of exhaled-breath volatile organic compounds to diagnose pancreatic cancer. Br J Surg, 105, 1493-1500.

 

Markar, S. R., Mackenzie, H., Ni, M., Huddy, J. R., Askari, A., Faiz, O., Griffin, S. M., Lovat, L. & Hanna, G. B. 2018b. The influence of procedural volume and proficiency gain on mortality from upper GI endoscopic mucosal resection. Gut, 67, 79-85.

 

Markar, S. R., Wiggins, T., Antonowicz, S., Chin, S. T., Romano, A., Nikolic, K., Evans, B., Cunningham, D., Mughal, M., Lagergren, J. & Hanna, G. B. 2018c. Assessment of a Noninvasive Exhaled Breath Test for the Diagnosis of Oesophagogastric Cancer. JAMA Oncol, 4, 970-976.

 

Roberts, H. W., Wagh, V. K., Mullens, I. J. M., Borsci, S., Ni, M. Z. & O’brart, D. P. S. 2018. Evaluation of a hub-and-spoke model for the delivery of femtosecond laser-assisted cataract surgery within the context of a large randomised controlled trial. Br J Ophthalmol, 102, 1556-1563.

 

Uchegbu, I., Sato, M., Allam, A., Buckle, P. & Hanna, G., 2018. The challenges of patient and public involvement in medical technology and in-vitro diagnostic research. Research for All, 2(2), pp.335-346. doi: https://doi.org/10.18546/R4A.02.2.11.


Preprints

A selection of recent preprints* involving members of the NIHR London IVD is included below.

(*A preprint is a full research paper, shared publicly before peer review.)

 

 

2021

 

 

Kierkegaard, P., Micocci, M., McLister, A., Tulloch, J., Parvulescu, P., Gordon, A. & Buckle, P. Implementing lateral flow devices in long-term care facilities: Experiences from the Liverpool COVID-19 community testing pilot in care homes— a qualitative study. 2021. https://papers.ssrn.com/abstract=3825945 (last accessed 20 Apr 2021).

 

Kierkegaard, P., Hicks, T., Yang, Y., Lee, J., Hayward, G., Turner, P. J., A. Joy Allen, & Nicholson, B. D. (2021). Primary care and point-of-care testing during a pandemic: Clinician’s perspectives on integrating rapid testing for COVID-19 into the primary care pathway. medRxiv. https://doi.org/10.1101/2021.04.13.21255347

 

Kierkegaard, P., Hicks, T., A. Joy Allen, Yang, Y., Hayward, G., Glogowska, P. Nicholson, B. D. & Buckle, P. (2021). Strategies to implement SARS-CoV-2 point-of-care testing into primary care settings: A qualitative secondary analysis guided by the Behaviour Change Wheel, 13 May 2021, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-501710/v1]

 

Micocci, M., Buckle, P., Hayward, G., Allen, A.J., Davies, K., Kierkegaard, P., Spilsbury, K., Thompson, C., Astle, A., Heath, R. and Sharpe, C. Point of Care Testing using rapid automated Antigen Testing for SARS-COV-2 in Care Homes-an exploratory safety, usability and diagnostic agreement evaluation. medRxiv 2021;:2021.04.22.21255948. Available online at: https://www.medrxiv.org/content/10.1101/2021.04.22.21255948v2 (last accessed 6 May 2021)

 

Micocci, M.; Borsci, S.; Thakerar, V.; Walne, S.; Manshadi, Y.; Edridge, F.; Mullarkey, D.; Buckle, P.; Hanna, G. Do GPs Trust Artificial Intelligence Insights and What Could This Mean for Patient Care? A Case Study on GPs Skin Cancer Diagnosis in the UK. https://www.preprints.org/manuscript/202105.0005/v1

 

Tulloch, J., Micocci, M., Buckle, P., Lawrenson, K., Kierkegaard, P., McLister, A., Gordon, A., García-Fiñana, M., Peddie, S., Ashton, M. and Buchan, I. Enhanced Lateral Flow Testing Strategies in Care Homes Are Associated with Poor Adherence and Were Insufficient to Prevent COVID-19 Outbreaks: Results from a Mixed Methods Implementation Study. SSRN Electron J Published Online First: 8 April 2021. https://papers.ssrn.com/sol3/papers.cfm 

 

Urwin S, B. Clare Lendrem, Jana Suklan, Kile Green, Sara Graziadio, Peter Buckle, Paul M. Dark, Adam L. Gordon, Daniel S. Lasserson, Brian Nicholson, D. Ashley Price, Charles Reynard, Mark H. Wilcox, Graham Prestwich, Valerie Tate, Tristan W. Clark, Raja V. Reddy, Richard Body, A. Joy Allen FebriDx point-of-care test in patients with suspected COVID-19: a pooled diagnostic accuracy study medRxiv 2020.10.15.20213108; doi: https://doi.org/10.1101/2020.10.15.20213108